Melphalan neurotoxicity
WebHigh-dose melphalan has been given intravenously in some malignancies: doses of 100–240 mg/m 2 have been used for neuroblastoma, and … Web20 nov. 2009 · Primary systemic amyloidosis (AL) is a monoclonal plasma cell disorder associated with progressive organ dysfunction and short survival. Standard therapy for …
Melphalan neurotoxicity
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WebHigh doses of melphalan (100–180 mg/m 2), either alone or in conjunction with bone marrow transplantation (up to 260 mg/m 2), have been associated with bone marrow … Web5 nov. 2024 · Melphalan treatment induces cell death and apoptosis in hiPSC-CMs. To investigate the cardiotoxicity of melphalan, we generated enriched hiPSC-CMs (Fig. S1) and treated them with melphalan at 4 doses ranging from 0 to 20 μM; the highest dose was slightly above the C max of melphalan (15.4 μM) []. hiPSC-CMs exposed to 20 μM …
Web6 feb. 2024 · Drawing parallels from other inflammatory syndromes presenting with TMAs, complement inhibition could be a promising therapy for CAR-T cell neurotoxicity. 94 A brief course of these agents can be considered in life-threatening or severely refractory cases while further research into the preemptively use these strategies is ongoing. Web13 mrt. 2024 · A case report: high dose melphalan as a conditioning regimen for multiple myeloma induces sinus arrest eCollection 2024. Authors Liang-Liang Ma # 1 , Ying Liu # 2 , Si-Xun Jia 3 , Hai-Chen Lv 2 , Mei-Yun Fang 3 , Yun-Long Xia 2 Affiliations 1 1Department of Hematology, the First Affiliated Hospital of Dalian Medical University, Dalian, China.
Web5 sep. 2024 · Melphalan has been shown to cause genotoxic effects and it has been classified by International Agency for Research of Cancer as an agent carcinogenic to … Web29 jun. 2015 · With the introduction of high-dose melphalan (HDM) followed by autologous stem cell ‘transplantation' (ASCT) and the use of new agents, the outcomes of patients with multiple myeloma have steadily improved. However, multiple myeloma is still an incurable disease, and patients will eventually relapse after front-line therapy.
Web27 sep. 2024 · Multiple myeloma (MM) is a malignancy of terminally differentiated plasma cells, and accounts for 10% of all hematologic malignancies and 1% of all cancers. MM is characterized by genomic instability which results from DNA damage with certain genomic rearrangements being prognostic factors for the disease and patients’ clinical response. …
Web20 mei 2012 · Abstract 6546 Background: High dose melphalan (HDM) at 200 mg/m 2 is the standard preparative regimen for patients with multiple myeloma (MM) and light-chain amyloidosis (AL) undergoing autologous hematopoietic stem cell transplantation (auto … secret of pharaoh dual eyebrowWeb29 jun. 1998 · Major dose-limiting factors of high-dose thiotepa (TEPA) and melphalan are life-threatening mucositis and neurotoxicity. To administer a maximum dose of these drugs safely and to obtain a maximum ... secret of pharaoh hair and body glitterWeb15 nov. 2005 · RATIONALE: Drugs used in chemotherapy, such as melphalan, work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing. ... MTD = dose of Melphalan that produces grade 3 neurotoxicity in 33% of subjects. Secondary Outcome Measures : secret of pets castWeb17 feb. 2024 · (1) Background: High-dose chemotherapy (HDCT) before autologous stem cell transplantation (ASCT) in acute myeloid leukemia (AML) patients predominantly combines busulfan with cyclophosphamide or melphalan. Treosulfan compares favorably regarding lower inter-individual bioavailability and neurotoxicity, but so far, had not … purchase rabbits onlineWeb14 jan. 2024 · A 63-year-old man developed encephalopathy and neurotoxicity during treatment with melphalan [route and duration of treatment to reaction onset not stated] … secret of photo 51 movieWeb13 sep. 2016 · Abstract. Objective: To evaluate long-term lenalidomide neurotoxicity and correlation with cumulative dose and hematologic response. Methods: Nineteen … secret of photo 51 summaryWebA 33-year-old woman developed neurotoxicity and gum infection during treatment with melphalan, prednisone and thalidomide (MPT) regimen for POEMS syndrome IgG4 subtype [routes not stated]. The woman, who was diagnosed with POEMS syndrome IgG4 subtype, was started on MPT regimen (28 days/each cycle), which included melphalan 4 mg/(m 2 secret of pivot boss pdf free download