Dengue virus effect on megakaryocyte biology
WebAbstract. Dengue virus infection has been counted among emerging and re-emerging diseases because of (1) the increasing number of patients, (2) the expansion of epidemic areas, and (3) the appearance of severe clinical manifestation of dengue hemorrhagic fever (DHF)/dengue shock syndrome (DSS), which is often fatal if not properly treated. WebJun 15, 2016 · Megakaryocyte–erythrocyte progenitor (MEP) cells are potential in vivo targets of dengue virus (DENV); the virus has been found associated with megakaryocytes ex vivo and platelets during DENV-induced thrombocytopenia. We report here that DENV serotype 2 (DENV2) propagates well in human nondifferentiated MEP cell lines (Meg01 …
Dengue virus effect on megakaryocyte biology
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WebNov 25, 2024 · Dengue virus does not affect megakaryocyte viability in vitro. Since DENV infects human megakaryocytes in vitro, ex vivo, and in vivo models of infection … WebNov 11, 2024 · Dengue virus (DENV) infection causes dengue fever in humans, which can lead to thrombocytopenia showing a marked reduction in platelet counts, and dengue …
WebJun 25, 2024 · 24 of virus by differentiated cells. On the other hand, DENV replication in cells undergoing PMA-induced 25 differentiation, interferes with major differentiation … WebMay 9, 2024 · IFITM3 is a 133-amino acid protein that disrupts cholesterol homeostasis, thus inhibiting the entry of several viruses (including influenza and dengue viruses) to …
WebMar 7, 2024 · Platelets were mainly associated with coagulation and hemostasis; however, other biological effects have been attributed to platelets, including angiogenesis, extracellular matrix synthesis, inflammation, and immune response. Dengue virus infection causes 200 million cases of severe flu-like illness annually, escalating to life-threatening … WebNov 4, 2024 · Dengue is transmitted to humans through the bite of certain species of Aedes mosquitos that carry one of the virus’s four serotypes: dengue viruses 1–4. These mosquitos mostly inhabit ...
WebJun 28, 2024 · Introduction. Dengue is a febrile illness caused by dengue virus (DENV) infection. The clinical manifestations of dengue occur on a spectrum, ranging from asymptomatic or a mild flu-like syndrome known as classic dengue fever (DF), to a more severe form known as dengue hemorrhagic fever (DHF) and the potentially fatal dengue …
WebJun 24, 2016 · Dengue Fever Biology & Transmission. Dengue has emerged as a global health threat, while scientists still know little about how the virus infects cells and causes … matthew altamuraWebJun 1, 2008 · In summary, dengue 2 viruses might infect megakaryocytic progenitors during the early viremic phase of infection and, depending upon both host and viral … hercules fx 200 priceWebJun 25, 2024 · 24 of virus by differentiated cells. On the other hand, DENV replication in cells undergoing PMA-induced 25 differentiation, interferes with major differentiation markers of Megakaryopoiesis including activation of 26 ERK1/2 MAP Kinase, endomitosis and surface expression of platelet-specific proteins without any drastic 27 effect on cell death. matthew altick attorney dallasWebJun 24, 2016 · Dengue Fever Biology & Transmission. Dengue has emerged as a global health threat, while scientists still know little about how the virus infects cells and causes the disease. To answer these questions, NIAID supports a wide-range of basic research activities aimed at better understanding the biology of the dengue virus, the … matthew alter mdWebJan 20, 2024 · The immune potential of platelets is dependent in part on their megakaryocyte precursor providing them with the molecular composition to be first responders and immune sentinels in initiating and … hercules fx300WebJan 25, 2024 · Fitness effects of mutations in the conserved structures reveal differences in fitness effects associated with SLI and SLII in human- and mosquito-adapted dengue virus populations. ( i ) Nucleotide-resolution map of fitness effects on the viral 3′ UTR reveals regions of SL1 and 2 that are under tighter constraints in human passage. matthew altieri doWebThis vaccine, which appears to predispose dengue-naïve recipients to an increased risk of hospitalization in the future, is recommended by the World Health Organization only for adults with a history of prior dengue virus infection. A safe and efficacious dengue vaccine continues to be sought globally. India has joined these efforts in recent ... hercules g1600 water pump